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KMID : 1059520080520040380
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Journal of the Korean Chemical Society
2008 Volume.52 No. 4 p.380 ~ p.386
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Inhibitory Effect of PMMA Denture Acrylic Impregnated by Silver Nitrate and Silver Nano-particles for Candida Albicans
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Lee Chul-Jae
Nam Ki-Young
Lee Mu-Sang
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Abstract
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PMMA denture acrylic resin impregnated by Ag (silver nitrate and silver nano-particles) was evaluated for the growth-inhibitory effect against Candida albicans. The 2 patterns of Ag impregnation to heat-polymerized PMMA resin was prepared as Ag-polymer and Ag-monomer with the concentrations of 0.002, 0.01 and 0.05 M respectively (control: 0M Ag). These modified resin disc specimens were inoculated with 100 μl fungal suspension (1.73×107 cells/ml) with incubation for 24 hours and growth-inhibitory effects were evaluated as the number of colony forming unit(CFU) on the specimen. Significant reduced CFU was found in the concentration of 0.05 M (72.8~80.9%) and 0.01 M(44.5~55.5%) Ag impregnated (p<0.01) without significant differences between silver nitrate and silver nano-particles and Ag-polymer and Ag-monomer (p>0.01). Elution of silver ions (Ag+) from the specimen by Atomic absorption spectrophotometer(AAS) may have contributed a little to the inhibition of fungal growth considering minimum inhibitory concentration (MIC) value in this study. The physical properties of modified denture acrylic confirmed with International organization for standardization (ISO) standard as examined by 3-point flexural strength test, however, color stability was proved to be poor for clinical use.
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KEYWORD
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Silver, Denture Acrylic Resin, Anti-Bacterial Properties, Candida Albicans
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